IL-1 genotype and adult periodontitis among young New Zealanders

NZ Literature Abstract

posted by Research Admin on 25 May 2010

Authors

W. Murray Thomson
S. J. Edwards
D. P. Dobson-Le
G. R. Tompkins
Richie Poulton
D. A. Knight
A. W. Braithwaite

Year of Publication

2001

Source

Journal of Dental Research, 80(8), 1700-3

Publication Type

Journal article (peer reviewed)

Publication Status

Completed

Abstract

The aim of this study was to investigate the association between adult periodontitis and IL-1 genotype in a population-based sample of 26-year-olds. Based on probing depth measurements, participants were divided into three disease groups: Severe, Moderate, and Controls. The periodontitis-associated genotype was present in 20.0% of the Severe group and in 34.8% of Controls, whereas the IL-1A/IL-1B genotype was present in 12.0% and 0.9%, respectively. After controlling for sex, smoking status, and plaque levels, it was found that those with IL-1B/IL-1A had 12.3 times the odds of being in the Severe group. The authors conclude that the IL-1A/IL-1B genotype is associated with periodontal disease in this population.

Type of Study

Quantitative, Prospective cohort study

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